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Data obtained were statistically analyzed with the IBM SPSS by ANOVA Method version 21.0 probability value 0.05). Conclusion Celery extract has better ability to break down kidney stones than apigenin. Copyright © 2019 Journal of Pharmacy and Bioallied Sciences.Background Antioxidants are chemical compounds that can donate one or more electrons to free radicals to prevent degenerative diseases. The crown of pineapple (Ananas comosus (L.) Merr.) contains bromelain, that is, a proteolytic enzyme, which can act as an antioxidant. Aims and