https://smadsignal.com/index.p....hp/static-correction
This study demonstrates primary cilia's ability to detect and respond to nutrient levels by altering their length through a glutamine-dependent anaplerotic pathway, specifically with asparagine synthetase (ASNS). Nutrient deprivation triggers cilia elongation, a consequence of diminished mitochondrial function, reduced ATP levels, and AMPK activation, irrespective of mTORC1. Crucially, the removal and subsequent replenishment of glutamine are essential for inducing either ciliar
Gefällt mir
Kommentar
Teilen
