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Our findings suggest that family-related ACEs are not only related to health in the early life, but also to health outcomes in adulthood. Childhood friendships can reduce the adverse effects of ACEs on health outcomes throughout an individual's life course. Therefore, it is necessary to actively cultivate children's peer relationship networks and improve the quality of childhood friendship.The "Joint Initiative for Teaching and Learning on Global Health Challenges and One Health" targets education and training in Global Health Challenge