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otein isoforms also demonstrates the potential and importance of integrating proteomics into genome annotation in maize. Anthracyclines and trastuzumab can increase the risk of heart failure (HF), but long-term cardiotoxicity data in breast cancer (BC) patients treated at younger ages are limited. Furthermore, it is unknown whether aromatase inhibitors are associated with HF risk. HF risk was studied in a multicenter cohort of BC survivors treated during 2000-2009, at age 61years. Information on treatment and cardiovascular disease