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05). Refractory COVID-19 patients were more likely to receive oxygen, mechanical ventilation, expectorant, and adjunctive treatment including corticosteroid, antiviral drugs and immune enhancer (P less then 0.05). After adjustment, those with refractory COVID-19 were also more likely to have a male **** and manifestations of anorexia and fever on admission, and receive oxygen, expectorant and adjunctive agents (P less then 0.05) when considering the factors of disease severity on admission, mechanical ventilation, and ICU transfer. CONCL
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