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The presence of the C allele is linked to diminished PPARGC1A mRNA and PGC-1 protein levels, accompanied by perturbed PGC-1 turnover dynamics and activity, thereby influencing cellular differentiation and mitochondrial function. Our experimental research offers the first insights, based on experimental data, into the effects of rs8192678 on the traits of adipocytes. Within the medical community, there has been a surge in interest in how body compo