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The antibody responses following IVR-190mg immunization are markedly enhanced, exhibiting higher hemagglutination-inhibition titers, more potent neutralization activity, elevated levels of anti-HA head domain antibodies, increased anti-HA stem antibodies, greater neuraminidase activity inhibition, and a substantial rise in antibody-dependent cellular cytotoxicity. The IVR-190mg treatment also resulted in a more balanced Th1/Th2 response and spurred a more comprehen