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The occurrence of spinal drop metastasis in patients diagnosed with glioblastoma multiforme (GBM) is rare. In previous reports, this diagnosis occurred after surgical resection of GBM, which was believed to increase the likelihood of tumor seeding. Diagnosis of spinal drop metastasis prior to surgery remains rare. We report a 57-year-old woman with a brief history of confusion, altered behavior, and agitation without any other significant past medical history. Computed tomography and magnetic resonance imaging (MRI) of