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05). There were statistically significant differences in lymphopenia, increased C-reactive protein and abnormal chest CT between children and adult patients (P 0.05). Twenty-seven families reported adults as first case of COVID-19 in family clusters. The same virus strain can cause milder disease in children compared with their caregivers. Children of COVID-19 were infected by adults in family during the early epidemic period. Asymptomatic patients can transmit the virus. The same virus strain can cause milder disease in children