https://www.selleckchem.com/pr....oducts/canagliflozin
Significance Statement Huntington's disease (HD) is a neurodegenerative disease characterized by prominent motor manifestations in addition to nonmotor changes in behavior and cognition. Several studies have provided evidences that the neuropathological hallmark of HD begins and progresses before the conventional diagnosis can be made. Here using an animal model, we identified deficit in motor skill in early stage of the disease. Remarkably these early behavioural deficits are accompanied by aberrant plasticity at synapses between
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