https://www.selleckchem.com/products/amg-487.html
The analysis of DRC for the metamizole+hesperidin combination, in a ratio 11 showed a ED value lower than the ED estimated from the additivity line from the isobologram (46.7±6.3 vs. 96.7±11.9mg/kg, respectively). In addition, the pharmacological interaction calculated was of 0.48. These results suggest a synergistic interaction for the antinociceptive activity of metamizole+hesperidin combination. These data suggest that metamizole+hesperidin combination could be useful in treating visceral pain as it can interact synergistically using
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