https://ifsp1activator.com/ner....ve-symptoms-in-inten
The present study describes the construction and analysis of an in vitro model of HGSC, using TP53 mutations to transform mouse oviductal epithelial cells (OVEs). The missense p53R175H mutant, when expressed in OVE cells, yielded a rise in both spheroid survival and the ability to proliferate independently of anchorage, relative to control OVE parental and Trp53 knockout cells. Transcriptomic analysis of spheroids identified a diminished apoptotic signaling response,
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