https://www.selleckchem.com/pr....oducts/nvp-dky709.ht
Subjects were enrolled in the study between 2013 and 2015, and the data analysis was carried out in 2016. The 3 dosing models were used for groups of 16, 15, and 15 subjects. The mean target dose significantly decreased from 6.63 g/day (Model 1) to 4.06 g/day (Model 3) (p=0.001). Compared with the static strategy of dosing with a single model, the dynamic modeling reduced the dose significantly by about 1.38 g/day on average. A Bayesian design was effective in adaptively revising the dosing algorithm, resulting in a lower pill burden
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