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Hybrid membranes, a fusion of mesenchymal stem cell membranes (MSCm) and pH-sensitive liposomes (pSL), are crucial to the biomimetic nanoplatform's capacity to target the tumor microenvironment (TME) and circumvent the endo/lysosomal system after endocytic internalization. Macrophage M1 phenotype repolarization, STING pathway activation, cytotoxic T lymphocyte (CTL) infiltration, and remarkable tumor inhibition are all effects of HM-BPT treatment, as observed