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In the present review, an effort has been made to summarize the key role of HIF-1α to maintain gut homeostasis. Highlights - Explain the molecular process of host microbial molecular interactions.- Establish the explicit role of HIF-1α in intestinal epithelial integrity and gut health.- Regulation of HIF-1α by human gut commensals and vice a versa.- Regulation of the host immune response for survival and colonization of human gut commensal.Using a novel tissue-clearing method, we aimed to visualize the three-dimensional (3D) distribution
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