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g. mobile or sedentary). Efficient bone regeneration using recombinant human bone morphogenetic protein-2 (BMP-2) is needed to reduce side effects caused by high-dose BMP-2 use. The composite material of polylactic acid-polyethene glycol (PLA-PEG) for sustained release and an osteogenic nano-hydroxyapatite (nHAp) can contribute to efficient bone regeneration by BMP-2. An experimental in vitro and in vivo study. The objective of this study is to investigate the effectiveness of a novel composite material of PLA-PEG and nHAp as a carrier for