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This preliminary study aimed to evaluate whether a homeopathic preparation ( ) might be a good option to control post-operative outcomes (pain, edema and trismus) associated with surgical removal of mandibular third molar teeth. The null hypothesis was that is not different from dexamethasone (gold standard) in controlling these post-operative inflammatory complications. A randomized, "split-mouth", triple-blind clinical trial was conducted. Seventeen healthy patients with a mean age of 20.94 ( ± 5.83) years had their lower asymptomatic