https://www.selleckchem.com/pr....oducts/elacestrant.h
The role of leptin in the development of intestinal inflammation remains controversial, since proinflammatory and anti-inflammatory effects have been described. This study describes the effect of the absence of leptin signaling in intestinal inflammation. Experimental colitis was induced by intrarectal administration of trinitrobenzene sulfonic acid (TNBS) to lean and obese Zucker rats (n = 1. Effects on inflammation and mucosal barrier were studied. Bacterial translocation and LPS concentration were evaluated together with coloni
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