https://www.selleckchem.com/MEK.html
05. The cell cycle of Calu-6/S100A6 cells had a reduction of S phase and an increase of G1 phase (P less then .05). In animal study, after 5 weeks of cell injection, the tumour bulk of Calu-6/S100A6 group was smaller than controls, with P less then .05. Our results demonstrate S100A6 inhibits the growth of Calu-6 lung cancer cells, as well as impairs Calu-6's ability in tumorigenesis. At cellular level, S100A6 is supposed to act as a tumour suppressor gene in lung cancer. Methotrexate (MTX) is an important agent for the treatment of primary cent