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The research will be conducted in alignment with the ethical principles of the Declaration of Helsinki and the legal framework of Japan's Clinical Trials Act. With reference K2021004, the Certified Review Board of National Cancer Center Hospital East approved the study's protocol. The study's registration, version 30, dated November 2021, is available at https://jrct.niph.go.jp/en-lat....est-detail/jRCTs0312 and is part of the Japan Registry of Clinical Trials (jRCTs031210593). The Ja
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