https://www.selleckchem.com/pr....oducts/gsk269962.htm
7x10-14). The number of rare nonsynonymous variants in VWF as well as the presence of a variant with CADD 20 are both significantly associated with VWF levels. The association with rare nonsynonymous variants holds even when controlling for known pathogenic variants, suggesting that additional variants, both in VWF or elsewhere, are also associated with VWFAg levels. Patients with higher VWFAg levels who have fewer rare nonsynonymous variants in the VWF gene could benefit from next-generation sequencing to find the cause of their
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