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Immune checkpoint expression kinetics revealed differences in magnitude between CD4+ and CD8+ T cells independent of age and ****. Further analysis of CD4+ T-cell subsets revealed an age-associated decrease of especially PD-1 + CD4+ memory T cells which tracked with the female ****. Collectively, our results demonstrate that both age and **** modulate expression of immune checkpoints by human T cells. These findings may have implications for optimising vaccination and immune checkpoint immunotherapy and move the field towards precision medi