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We investigated the synergistic effect between vancomycin and ß-lactams against vancomycin-susceptible (VSSA) and non-susceptible MRSA isolates (heterogeneous vancomycin-intermediate S. aureus (hVISA) and VISA). A total of 29 MRSA including 6 VISA, 14 hVISA and 9 VSSA isolates were subjected to a microbroth dilution-minimum inhibitory concentration (MIC) checkerboard using vancomycin combined with cefotaxime, imipenem or meropenem. To confirm synergistic activity, the representative strains of VISA, hVISA and VSSA were then selected for