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A symptom of diabetic neuropathy, diabetic neuropathic pain, is profoundly debilitating and gravely affects the well-being of those afflicted. Currently, there are no dedicated therapies available for DNP, save for duloxetine and gabapentin, which show limited success in addressing DNP's symptoms. In this review, the central function of protein kinases in DNP pathogenesis and their therapeutic manipulation are discussed. A search of Scop