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Nanoparticles with a pH dependent phase transition as described in this study may be useful as drug delivery carriers for the treatment of cancers and certain bacterial infection.It is generally thought that liquid-liquid phase transition (LLPT) in a one-component suspension never or only very rarely happens. If this were true, it would contradict the two nonclassical nucleation models building on either liquid droplets or prenucleation clusters (PNCs). One way out of this paradox is to suppose that LLPT occurs in pathway to nucleation.