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Approximately 25 million Americans are impacted by the prevalent eyelid ailment, Demodex blepharitis. The present article investigates Demodex blepharitis, encompassing its mechanistic underpinnings, repercussions, predisposing factors, visible signs and symptoms, diagnostic procedures, current therapeutic modalities, and upcoming treatment advancements. The multifaceted involvement of Demodex mites in blepharitis encompasses their physical da