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Antibiotic resistance is a grave threat for public health. Understanding the mechanisms of resistance could lead to new drugs and therapeutic strategies against resistant pathogens. © 2020 The Authors.Dimeric polyketides are widespread fungal secondary metabolites. They occur in both ascomycetes and basidiomycetes and, therefore, across fungal phyla. Here we report the isolation of a new binaphthalene, named rufoschweinitzin, from the basidiomycete Cortinarius rufoolivaceus. Rufoschweinitzin consists of two symmetrically 4,4'-coupled to
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