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The levels of STAT3 and AKT2 decreased substantially in the liver and muscle tissue of mice overexpressing IGF2, in contrast with an increase in AKT2 expression exclusively in the muscle tissue. IGF2 overexpression in mice led to a substantial enhancement of GLUT2 expression in the liver, kidneys, and muscles, but a contrasting decrease was seen in the pancreas. This research also indicated that in norm