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Compared to healthy individuals, asthma patients showed an increase in sputum eDNA. A positive association was found between eDNA and sputum neutrophils in asthma patients, contrasting with the inverse relationship between eDNA and FEV1%predicted. In TDI-induced asthmatic mice, the following parameters were significantly increased: airway inflammation, airway reactivity, Th2 cytokine concentrations in lymph supernatant, and NET levels. The increases in question were not quelled by dexamethasone, whereas DNase I did. Following the inhibition of NETs, TDI-stimu
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