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5% vs. 8.9%; OR = 0.82; 95% CI 0.78-0.86; p less then 0.001). However, the prevalence rates of pulmonary hemorrhage and necrotizing enterocolitis (NEC) were greater in PDA-ligated infants (OR = 1.58; 95% CI 1.49-1.67; p less then 0.001, and OR = 1.32; 95% CI 1.26-1.38; p less then 0.001, respectively). CONCLUSIONS Ligation of PDA has been steadily declining since 2004. Despite higher morbidities, PDA-ligated infants had less mortality. V.This study evaluates the possible protective effects of gallic acid (GaA) and ferulic acid (FeA) ag