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38 ± 7.82 vs. 35.32 ± 5.54, P 0.001) and one month following intervention (44.67 ± 3.47 vs. 35 ± .54, P 0.001). Moreover, the mean sleep quality scores of the experimental group was significantly greater than that for control group immediately (5.35 ± 2.02 vs. 7 ± 2.4, P = 0.004) and one month after the intervention (4.23 ± 2.2 vs.7.02 ± 3.03, P 0.001). Since our training program on positive thinking improved hope and quality of sleep in patients with thalassemia major, we recommend the use of such courses as an