https://www.selleckchem.com/pr....oducts/PHA-665752.ht
The gREST method can be applied to the examination of structure-activity relationships for multiple VDR-LBD ligands.Erdafitinib (ERD) is a first-in-class pan inhibitor of fibroblast growth factor receptor 1-4 that has garnered global regulatory approval for the treatment of advanced or metastatic urothelial carcinoma. Although it has been previously reported that ERD elicits time-dependent inhibition (TDI) of cytochrome P450 (P45 3A4 (CYP3A4), the exact biochemical nature underpinning this observation remains obfuscated. Moreover,
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