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It was observed that these parameters were improved at a significant level in agomelatine 1 mg/kg and agomelatine 5 mg/kg groups when compared to ulcer group; and the results were similar to omeprazole group. It was also observed that our histopathological findings were consistent with all our other results. CONCLUSIONS The results of this study showed that agomelatine usage in indomethacin-induced gastric ulcer model provides beneficial results.BACKGROUND The goal of our study was to examine the long-term effect of vigabatrin