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Male ****, being from a European cohort, vertically-acquired HIV, and current severe immunosuppression, viral load 400 copies/mL, older age and, for those not on treatment, earlier calendar year, were risk factors for a malignancy diagnosis. 58 (41%) of individuals with a malignancy died, a median 2.4 months (IQR 0.6, 8.8) after malignancy diagnosis. The rate of ADM has declined since widespread availability of combination ART, although of NADM there was a small increase. Mortality following a malignancy was high, warranting further in