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proach includes genomic, epigenomic and functional studies, which results will contribute to the improvement of the diagnosis, prognosis and personalized therapy of FH patients. The aim of this study was to test whether an investigational two layer stocking exerting 27-29mmHg pressure at the medial supramalleolar level, but without compression in the foot and heel, is easier to put on and take off than a standard stocking of the same compression class (23-32mmHg), and also to assess the prevention of diurnal oedema with both types of st