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A total of 171 patients were included (n = 51 [no comorbidities], n = 73 [mild CCI], and n = 47 [moderate CCI]). Higher CCI patients were older and more likely to be smokers, diabetic, arthritic, hypertensive, or have a malignancy history ( 0.003). Preoperatively, ODI and PROMIS PF were the only patient-reported outcomes with a significant association by CCI group ( = 0.015 and 0.014). Back pain was the only measure that had a significant association with the CCI subgroup at 1 year for score ( = 0.002) or MCID