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hway, especially during the COVID-19 emergency.As a very important research direction in the field of bioinformatics, sequence alignment plays a vital role in the research and development of biology. Converting genome sequence to graph by using frequency chaos game representation (FCGR) is an excellent gene sequence mapping technology, which can store rich genetic information into FCGR graphics. To each FCGR image, we construct its perceptual image hashing (PIH) matrix using the bicubic interpolation zooming. The difference of the percep
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