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79) or Xinyi county (aOR = 0.33, 95% CI 0.20-0.53), had a university or higher degree (aOR = 0.26, 95% CI 0.11-0.64), had good knowledge of EV71 vaccines (aOR = 0.81, 95% CI 0.67-0.98), perceived their children's disease susceptibility, and worried about the severity of HFMD had a higher willingness to vaccinate their children. Most parents were willing to vaccinate their children against EV71-related HFMD. Parental age, location, education level, knowledge of EV71 vaccines, concern about susceptibility, and severity of HFMD were all fac