https://www.selleckchem.com/pr....oducts/clozapine-n-o
DNA ****tion forks are constantly challenged by DNA lesions induced by endogenous and exogenous sources. DNA damage tolerance mechanisms ensure that DNA ****tion continues with minimal effects on ****tion fork elongation either by using specialized DNA polymerases, which have the ability to ****te through the damaged template, or by skipping the damaged DNA, leaving it to be repaired after ****tion. These mechanisms are evolutionarily conserved in bacteria, yeast, and higher eukaryotes, and are paramount to ensu
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