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The pigs' pancreas showed a moderate level of structural changes, namely pathomorphological, 43 days after the pigs received the final cerulein injection. Following cerulein injections, elevated levels of interleukin (IL)-1-beta, IL-6, tumor necrosis factor alpha (TNF-alpha), C-reactive protein (CRP), lactate dehydrogenase (LDH), gamma-glutamyl transpeptidase (GGTP), superoxide dismutase (SOD), and glutathione (GSH) were observed in blood serum. An elevation in IL-1-beta,