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This produces decadal changes in EKE, with a similar pattern than that of strong EP El Niño events, resulting in a significant negative (positive) long-term trend off Peru (central Chile).Since melanomas often retain wild type p53, we developed an adenoviral vector, AdRGD-PG, which provides robust transduction and transgene expression in response to p53. Previously, this vector was used for interferon-β gene transfer in mouse models of melanoma, resulting in control of tumor progression, but limited cell killing. Here, the AdRGD-PG-hIF
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