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05). Patients with an elevated STB level showed increased mortality [hazard ratio (HR) 9.45, P = 0.002], elevated conjugated bilirubin (C levels (HR 4.38, P = 0.03), and an elevated ratio of CB to unconjugated bilirubin (UCB, CB/UC (HR 2.49, P = 0.01). CB/UCB was positively correlated with disease severity (odds ratio 2.21, P = 0.01). Conclusions COVID-19 patients with elevated STB and CB levels had a higher mortality, and CB/UCB was predictive of disease severity and mortality. Thus, it is necessary to pay special attention to COVI