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4%. Conclusion In summary, LAC-SFN/CCM-NPs was proved to be a promising system for targeted HCC therapy. © 2020 Bian and Guo.Purpose Inhaled nitric oxide (iNO) selectively vasodilates the pulmonary circulation but the effects are sometimes insufficient. Available intravenous (iv) substances are non-selective and cause systemic side effects. The pulmonary and systemic effects of iNO and an iv mono-organic nitrite (PDNO) were compared in porcine models of acute pulmonary hypertension. Methods In anesthetized piglets, dose-response experimen