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In the second group of mice, vehicle administration did not alter the setpoint (8.84 ± 0.69mg/dL to 8.98 ± 0.63mg/dL), but subsequent etelcalcetide administration significantly decreased it to 7.10 ± 0.72mg/dL. There was no significant change in maximum and minimum PTH secretion. Expression levels of parathyroid CaSR were lower in PC mice than in WT mice; however, no significant differences were observed between the two mouse groups. Etelcalcetide decreased the PTH-calcium setpoint without changing maximum and minimum PTH secretion in PC