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The purpose of this study was to evaluate the impact of the Coronavirus Disease 2019 (COVID-19) pandemic on ****ual behavior, mental health, and substance use among men who have **** with men (MSM) engaged in pre-exposure prophylaxis (PrEP) care. Generalized linear mixed models and logistic mixed-effect models examined change over time for number of ****ual partners, mood, and alcohol consumption. From February 29, 2020 to July 31, 2020, 177 MSM actively engaged in PrEP care were evaluated. The median age was 37 [interquartile range (IQR 30