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Anxiety, depression, and daytime sleepiness were more prevalent in patients with fatigue than in those without fatigue (all p-values 0.001). The prevalence of fatigue is high in contemporary patients with MS. Fatigue is associated with female **** and level of disability, as well as with anxiety, depression and excessive daytime sleepiness. The prevalence of fatigue is high in contemporary patients with MS. Fatigue is associated with female **** and level of disability, as well as with anxiety, depression and excessive daytime sleepi