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014). None of the analyzed microvascular parameters changed in response to the intervention. Despite favorable effects of HIIT on physical fitness of T1D patients, disease-specific training protocols may be needed to overcome potentially impaired retinal microvascular adaptations. Despite favorable effects of HIIT on physical fitness of T1D patients, disease-specific training protocols may be needed to overcome potentially impaired retinal microvascular adaptations.Toll-like receptor 2 (TLR2) is an important pattern recognition receptor