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These findings elucidate key ecological dynamics between SRB, methanogens, and syntrophic butyrate oxidizing bacteria which can be applied to a variety of engineered and natural systems. © FEMS 2020.As a subtype of non-small-cell lung cancer, lung squamous cell carcinoma (LUSC) accounts for one-fifth of all lung cancers. Unfortunately, no specific targetable aberration has yet been identified. Hence, it is of huge urgency and potential to identify aberrantly regulated genes in LUSC. Here, five pairs of LUSC samples and their correspondin