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Moreover, subgroup analyses demonstrated that the association between low AGR and worse OS remained constant despite variations in country, tumor stage, cut-off value, cut-off selection and treatment method. AGR could act as an efficient prognostic indicator for GC, and that low pretreatment AGR predicts poor prognosis in GC. AGR could act as an efficient prognostic indicator for GC, and that low pretreatment AGR predicts poor prognosis in GC.TBX1 belongs to an evolutionarily conserved family of transcription factors involved in organ deve