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05). While compared with the control group, the expression levels of HO-1 and CHOP protein were significantly increased in the lead exposure group (P less then 0.05), and the expression levels of HO-1 and CHOP protein were significantly reduced in the folic acid intervention group (P less then 0.05). In conclusion, lead exposure increased the expression levels of HO-1 and CHOP in the spleen of rats, and caused damage to the spleen. Folic acid down-regulated the expression levels of HO-1 and CHOP proteins through the two pathways of NrF
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